What caliber do you load up for personal protection? A lot of folks are carrying .380's these days because the 380 guns are so concealable, but the ammunition does not meet a lot of testing standards that the bigger calibers will provide. So what is your minimum caliber? In my opinion, having 2 shots of .22 in a derringer is better than the 15 rounds of 45acp that I left at home because it was too bulky to carry.
"Gun control is like trying to reduce drunk driving by making it tougher for sober people to own cars."